"How Psilocybin Mushrooms Change the Brain"

"Magic mushrooms may actually free the mind, a new study says. The compounds in the (illegal) mushrooms change the way the brain works. New research suggests that psilocybin, the main psychoactive ingredient in magic mushrooms, sprouts new links across previously disconnected brain regions, temporarily altering the brain's entire organizational framework.

These new connections are likely what allow users to experience things like seeing sounds or hearing colors. And they could also be responsible for giving magic mushrooms some of their antidepressant qualities.

When researchers compared the brains of people who had received IV injections of psilocybin with those of people given a placebo, they found that the drug changed how information was carried across the brain. (Subjects received 2 milligrams of psilocybin; the dose and concentration of the chemical in actual mushrooms — which are eaten, not injected — varies.) Typically, brain activity follows specific neural networks. But in the people given psilocybin injections, cross-brain activity seemed more erratic, as if freed from its normal framework.

When the researchers looked more closely, however, they noticed that the sparks of activity across the brains of their drugged volunteers wasn't as chaotic as it seemed.

Instead, the activity formed distinct patterns, or cycles.

"The brain does not simply become a random system after psilocybin injection," the researchers wrote, "but instead retains some organizational features, albeit different from the normal state."

Picture the information in your brain being shared across an interconnected and heavily-trafficked system of highways. In that example, psilocybin isn't removing the highways. Instead, it's simply building new ones.

These new connections allow parts of the brain that don't usually talk to one another to communicate. People who use magic mushrooms and see the number 52 as glowing bright blue and red, then, don't see it that way because the drugs have made them crazy. Instead, they associate the number with colors because the brain region that detects and interprets color has been chatting it up with the brain region that processes numbers.

This new insight into what psilocybin does to the brain could help explain years of earlier findings on psilocybin's psychological effects, including how magic mushrooms seem to curb symptoms of depression.

In a 2012 study, Imperial College London neuroscientist David Nutt found that in people drugged with psilocybin, brain chatter across traditional areas of the brain was muted, including in a region thought to play a role in maintaining our sense of self. In depressed people, Nutt believes, the connections between brain circuits in this sense-of-self region are too strong. "People who get into depressive thinking, their brains are overconnected," Nutt told Psychology Today. Negative thoughts and feelings of self-criticism become obsessive and overwhelming.

Loosening those connections and creating new ones, Nutt thinks, could provide intense relief…"